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Antibody production in patients hospitalized with COVID-19

Antibody-secreting cells (ASCs) peaked at 3-4 weeks and were still being produced at 3-4 months in patients hospitalized with COVID-19, according to a study published in the peer-reviewed journal Viral Immunology.

Diane Griffin, tylenol codeine enceinte MD, Ph.D., from Johns Hopkins Bloomberg School of Public Health, and coauthors, analyzed the blood of 55 patients hospitalized up to four months after onset of COVID-19 symptoms. They reported spike (S)- and nucleocapsid (N)-specific IgM and IgG ASCs within two weeks.

The investigators found that: “Patients with more severe disease produced more S-specific IgM and IgG ASCs than those with mild disease and had higher levels of both N- and S-specific antibody in plasma.” The findings predict a more durable immune response in patients recovering from more severe disease.

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